After working for Merck Sharp and Dohme, I started a PhD entitled 'Enhanced Prediction and Prevention of Torsades de Pointes' at Maastricht University as part of an industrial collaboration with Astrazeneca.
I am currently a post-doctoral researcher at K.U. Leuven
My research efforts centre around understanding the role of ion channels and calcium handling in arrhythmia formation as well as developing novel proarrhythmic markers.
FWO Postdoctoral Research Fellow
Since May 2013
Project Leader Safety Pharmacology
October 2011 --- October 2012
Bio-Plus Safety Pharmacology is a contract research organization providing fast, flexible and standardized solutions in the field of non-clinical cardiovascular safety (CVS) pharmacology. Within this field Bio-Plus-SP presents an unique product: “an integrated CVS-risk-assessment platform” enabling early screening at low cost, but with a validated outcome.
January 2005 --- January 2012
Over the last decades, drug induced cardiac arrhythmias, including Torsades de Pointes (TdP) have become a major issue in drug development. There is a pressing need for better understanding of the mechanisms involved in TdP manifestation to allow for enhanced prediction (via more predictive surrogate markers) and prevention of this arrhythmia (via novel targets). This thesis elucidates a number of cellular mechanisms involved in beat-to-beat variability of repolarization, which is one of the newer surrogate markers thought to have utility in predicting this arrhythmia. The thesis highlights the role of calcium release from the calcium store within the single myocyte in altering this parameter. Additionally the dissertation illustrates the link between mechanical and electrical activity under specific conditions and provides further validation of an additional novel marker for proarrhythmia (the electro-mechanical window). Finally, research contained within this thesis suggests antiarrhythmic strategies for the development of novel therapeutic agents.
January 2002 --- January 2005
During this period i worked in the neuroscience research centre,working on various projects, including TRPV1 channels using various electrophysiological techniques, such as patch clamp recordings in both native tissue and transfected cells
Doctor of Philosophy (PhD) in Cardiac Pharmacology/ Electrophysiology from Universiteit Maastricht / Maastricht University in 2012
BSc in Pharmacology from Newcastle University in 2002