July 2013 --- October 2014
Laboratory for Regenerative Medicine & Pharmacology (LMRP) Guidance: Prof. Jeffrey A. Hubbell Project: Photocleavable and redox-sensitive block copolymers for drug delivery and vaccine development - Development of stimuli-triggered vaccines using conjugated polymers to oligonucleotides and peptides. I synthesized, purified, characterized and assembled the conjugates into nanometric micelles of various formulations and they were studied in their in vivo application as vaccines. - Organizer of group meetings for the nanoparticle subdivision
July 2011 --- June 2013
Department of Chemical and Biomolecular Engineering Guidance: Prof. Dennis E. Discher. Project: Photocleavable and redox-sensitive block copolymers for drug delivery and vaccine development - Development of stimuli-sensitive worm-like micelles as drug delivery systems. Expanding into the field of drug delivery I synthesized, purified, characterized and assembled (DNA-)block copolymers into worm-like micelles that were implemented as successful drug delivery carriers for cancer treatment. The results are currently being written into a manuscript for submission. - Project supervisor and trainer of students at B.Sc., M.Sc. and Ph.D. levels. - Teaching "Nanoscale Systems Biology". - Responsible for the maintenance of the gel permeation chromatography (GPC) and high performance liquid chromatography (HPLC) machines. - Developer of scientific proposals. - Reviewer of manuscripts.
August 2006 --- April 2011
PhD student in Organic and Biomolecular Chemistry. Stratingh Institute for Chemistry. Promoters: Prof. Gerard Roelfes and Prof. Ben L. Feringa. Thesis title: Development of functional DNA-based systems (ISBN 978-90-367-4832-2) - Construction and application of DNA-based functional systems. In a promising but still emerging group in the field of DNA-based systems I established the conjugation of metal catalysts, peptides and organic molecules to oligonucleotides as well as their purification, assembly and application in catalysis, molecular sensing and light harvesting. As a result my work was published in several peer-reviewed scientific journals. - Project supervisor and trainer of students at B.Sc. and M.Sc. levels - Teaching of practical courses: "Organic Synthesis for Pharmacy" and "Synthesis and Analysis I" - Jury member in the 2007 Stratingh Award for the best student colloquium in the department of molecular organic and inorganic chemistry.
February 2011 --- March 2011
Researcher at the Stratingh Insitute for Chemistry under the supervision of Prof. Gerard Roelfes. Project: An ATP sensor based on DNA-directed split murine dihydrofolate reductase (DHFR) reassembly
September 2003 --- January 2004
Training at the gas chromatography department
Master's degree in Organic and Supramolecular Chemistry from Radboud Universiteit Nijmegen in 2006
Bachelor's degree in Organic Chemistry from Radboud Universiteit Nijmegen in 2004
Bachelor's degree in Chemistry from Universitat Jaume I in 2004