I am a reserach with interest in the neuroscience field, in particular em the molecular and cellular alterarions leading to a disease state.
I did my PhD investigating the effect of Brain derived-neurotrophic factor in the regulation of protein degradation, a key process for learning and memory, and also neuronal developement.
I then moved to Belgium to investigate the pathways altered in neurodevelopmental disorders, such as autism and schizophrenia.
Since January 2012
In December 2012 I have been awarded a Post-doc fellowship under the program omics@VIB
April 2011 --- December 2011
October 2006 --- January 2011
During my Phd I have been interested in investigating the effects of BDNF both at translation and degradation level. We have applied several cellular and molecular techniques to understand how the neurotrophin BDNF plays its important and crucial role for neuronal development. Main scientific achievements: The proteomics studies revealed targets of the long-term effect of BDNF signalling, showing for the first time that both protein synthesis and degradation are altered by BDNF. The functional studies together with biochemical evidences suggest that the decrease in proteasome activity induced by BDNF may be important for the induction phase of long-term potentiation. Furthermore, I have identified AMPA receptor regulators as new synaptic targets of the proteasome, which may be relevant in synaptic plasticity. Currently, experiments are being done to confirm the role of UPS in the AMPA receptor recycling, an event necessary for plasticity. Additionally, during my PhD I have started a new line of investigation in the lab, focusing on the regulation of a specific group of RNA-binding protein by BDNF. I’ve setup all the protocols in use and supervising all the work performed. We have identified the transcripts associated with hnRNP K and how the stimulation with BDNF alters the binding of hnRNP K with its targets mRNAs. Currently, several experiments are being performed to understand the functional effect on BDNF on hnRNP K function at synapse.
September 2005 --- June 2006
During my internship at Janssen pharmaceutic, a division of J&J, I was trained in animal handling and in vivo experiments. Back that time I was responsible to study and investigate the action of several drugs used in schizophrenia treatment. The main goal was to find a therapeutic with few side effects.
Doctor of Philosophy (Ph.D.) in Molecular and cellular Biology from Universidade de Coimbra in 2011
Bachelor in Biology/Biological Sciences, General from University of Coimbra in 2006
Licenciatura em Biologia in from Universidade de Coimbra in 2006
Expert has 5 publications (Will be avalible with full profile)