Ph.D. Student à l'Unité de recherche sur l'Os et le CartilageOctober 2010 --- November 2015
osteoarthritis is a disease with high prevalence and signifi cant socio-economic impact.
to date, osteoarthritis treatments are mainly symptomatic. joint replacement is provided for the
severe acute forms of the disease.
in this context, there is a real need to develop new treatments which are well tolerated and able
to prevent or delay the progression of the disease. in this objective, we have developed new Biomaterials
- beads and hydrogel - composed by non-animal chitosan.
in the fi rst part of this work, we have studied In Vitro human osteoarthritic chondrocytes behavior
embedded in chitosan-alginate beads. pro-infl ammatory, catabolic and anabolic mediators chondrocytes
production have been quantifi ed. in the second part, we have evaluated osteoarthritis
progression after chitosan-alginate beads intra-articular injection in anterior cruciate ligament transection
(aclt) rabbit model.
human osteoarthritis chondrocytes. indeed, less infl ammatory and catabolic mediators have been
produced while syntheses of specifi c components of the cartilage matrix were maintained.
in rabbits with aclt induced oa, chitosan-alginate beads dispersed in a chitosan hydrogel prevented
joint space narrowing and signifi cantly reduced the severity of histological cartilage lesions
in conclusion, chitosan-alginate beads are a good matrix for cartilage lesions Cell therapy and
represent an alternative to hyaluronic acid viscosupplementation.
Attaché de recherche. Unité de Recherche sur l’Os et le CartilageFebruary 2013 --- December 2014
Assistant volontaire au Département des Sciences de la MotricitéNovember 2010 --- October 2012
CommunicativeAdaptabilityAttention to detailCuriosityFlexibilityInnovative thinkingOrganizationResponsibility
Skills and Expertise
Develop protocols Technology research Write papersCollaborate with project teamConduct research at universitiesCoordinate ethics committeecoordinating research projectsDesign studyGeneral office managementInteract with pre-clinical scientistslifescienceManuscript preparation and reviewOral presentationPresent data at congress
Ph.D. in biomedical and pharmaceutical sciences from University of Liege in 2015
Certificat de formation continuée en animaux de laboratoire - catégorie C FELASA in from Université de Liège in 2011
Master's degree in Master en sciences biomédicales à finalité approfondie en pharmacologie et toxicologie from University of Liège in 2010
Expert has 4 publications (Will be avalible with full profile)