Ph.D. Student à l'Unité de recherche sur l'Os et le Cartilage
October 2010 --- November 2015
Osteoarthritis is a disease with high prevalence and signifi cant socio-economic impact.
To date, osteoarthritis treatments are mainly symptomatic. Joint replacement is provided for the
severe acute forms of the disease.
In this context, there is a real need to develop new treatments which are well tolerated and able
to prevent or delay the progression of the disease. In this objective, we have developed new biomaterials
- beads and hydrogel - composed by non-animal chitosan.
In the fi rst part of this work, we have studied in vitro human osteoarthritic chondrocytes behavior
embedded in chitosan-alginate beads. Pro-infl ammatory, catabolic and anabolic mediators chondrocytes
production have been quantifi ed. In the second part, we have evaluated osteoarthritis
progression after chitosan-alginate beads intra-articular injection in anterior cruciate ligament transection
(ACLT) rabbit model.
In vitro, we have shown benefi cial effects of this promising new biomaterial on the metabolism of
human osteoarthritis chondrocytes. Indeed, less infl ammatory and catabolic mediators have been
produced while syntheses of specifi c components of the cartilage matrix were maintained.
In rabbits with ACLT induced OA, chitosan-alginate beads dispersed in a chitosan hydrogel prevented
joint space narrowing and signifi cantly reduced the severity of histological cartilage lesions
In conclusion, chitosan-alginate beads are a good matrix for cartilage lesions cell therapy and
represent an alternative to hyaluronic acid viscosupplementation.
Attaché de recherche. Unité de Recherche sur l’Os et le Cartilage
February 2013 --- December 2014
Assistant volontaire au Département des Sciences de la Motricité
November 2010 --- October 2012
CommunicativeAdaptabilityAttention to detailCuriosityFlexibilityInnovative thinkingOrganizationResponsibility
Skills and Expertise
Develop protocols Technology research Write papersCollaborate with project teamConduct research at universitiesCoordinate ethics committeecoordinating research projectsDesign studyGeneral office managementInteract with pre-clinical scientistslifescienceManuscript preparation and reviewOral presentationPresent data at congress
Ph.D. in biomedical and pharmaceutical sciences from University of Liege in 2015
Certificat de formation continuée en animaux de laboratoire - catégorie C FELASA in from Université de Liège in 2011
Master's degree in Master en sciences biomédicales à finalité approfondie en pharmacologie et toxicologie from University of Liège in 2010
Expert has 4 publications (Will be avalible with full profile)