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Summary

after several years expanding the depth and breadth of my scientific Training as a pharmacologist in an academic setting, i look forward to applying my skills and experiences more directly to the development of novel therapeutics in the Pharmaceutical Industry. i am dedicated, adaptable, results-oriented, quality-minded, and i greatly enjoy collaborative/team-oriented environments. my strengths include: • over 10 years experience in academic Biomedical Research ranging from basic molecular and cellular Analysis to Preclinical models of human disease • preparing data/scientific material for manuscripts, Presentations and grant/award Applications • extensive methods development and optimization • Project Management and instruction/supervision of colleagues specialties: pharmacology, Signal Transduction, molecular biology, Biochemistry, Vascular biology, hematopoiesis, thrombosis, Cell biology, g-Protein coupled receptors

Experiences

Current Experience

  • Postdoctoral Researcher


    Since September 2015
    developing an effective transcriptional reporter assay as a downstream endpoint for gpcr activation/inhibition. aiming to apply the assay to both a multiwell plate format as well as an "on-bead" assay, where cyclized peptide ligands, attached to a peg-bead, can activate cells, bound to the beads, as a rapid means for screening libraries of peptide ligands. Developing an effective transcriptional reporter assay as a downstream endpoint for GPCR activation/inhibition. Aiming to apply the assay to both a multiwell plate format as well as an "on-bead" assay, where cyclized peptide ligands, attached to a PEG-bead, can activate cells, bound to the beads, as a rapid means for screening libraries of peptide ligands.

Past Experience

  • Postdoctoral Researcher

    February 2014 --- August 2014
    as part of a short-term industrial partnership, i supervised colonies of genetic strains of mice with an aim toward evaluating the role of an orphan gpcr in CNS function. i also completed as part of a team a high throughput screen of several thousand Small molecules against the same orphan gpcr in an attempt to identify new modulatory pharmacological scaffolds. areas of responsibility • primary goals were to characterize the In Vivo function of the orphan gprotein coupled receptor gpr139 using mouse “Gene knockout” models. supervised the transfer of the mice to a ku facility after backcrossing to a standard genetic background. harvested and sectioned brains for Validation of knockout and autoradiographical evaluation of a high affinity ligand. • additionally, completed a screen of a >4000 compound library against several gpcrs to identify possible positive and negative allosteric modulatory molecules using High Throughput Screening for Cell signalling endpoints • prepared final report for project

  • Associate Specialist

    October 2008 --- May 2012
    have driven studies characterizing the role of g-Proteins and gpcrs in the context of platelet function as it pertains to the processes of thrombosis and hemostasis in mouse models. areas of responsibility • specifically, i examined the roles of g-Protein coupled receptors and their associated signalling mechanisms in governing hematopoietic Cell biology, with a specific emphasis on blood platelets. • usage of Preclinical Animal models of disease was an important part of these studies. results • resulted in 9 Publications in high impact journals. • contributed to several collaborative studies. • developed and implemented several methods; emphasis on platelet function and Flow Cytometry

  • Postdoctoral Researcher

    October 2002 --- October 2008
    pursued several Research aims utilizing murine and zebrafish model systems to explore the roles of the alpha subunits of heterotrimeric g-Proteins and their cognate g-Protein coupled receptors in the context of innate immunity, hematopoiesis, and thrombosis.

Knowledge

LinkedIn Assessment :
pharmacologyBiochemistrymolecular biologyProtein ExpressionProtein PurificationCell CultureCell biologyCell Based AssaysCell SignalingAnimal Models of DiseaseThrombosisVascular BiologyFlow CytometryAnimal ModelsCellGeneticsSignal TransductionLaboratoryVascularClinical DevelopmentIn VivoFluorescence MicroscopyPhysiologyGPCRsConfocal MicroscopyscienceWestern BlottingTransfectionIn VitroMolecular CloningAssay developmentMicroscopyProject ManagementMethods OptimizationImmunofluorescenceTissue CultureLife Sciences

Education

  • PhD in Pharmacology and Toxicology from Queen's University in 2002
  • Bsc (Hons) in Life Sciences from Queen's University in 1996

Training and Certification

  • Fundamentals of Clinical Trials (Whitehall Training) in 0000 Certification
  • ICH GCP in English (Whitehall Training) in 0000 Certification
  • The Data Scientist’s Toolbox in 0000 Certification

Languages

BrightOwl Assessment:
Self Assessment:
English
Native
Danish
Elementary Proficiency
French
Elementary Proficiency

Area / Region

Copenhagen, Denmark

Others

Driving License
  • No

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