Head of Translational Pharmacology Lab
Since May 2009
Identification of biomarkers, development of bioassays to characterise and validate monoclonal antibodies. Toxicology, preclinical and clinical studies. Generation of data for clinical pharmacology (models) Manager of the Gene expression platform Implementation of a ISO 17025 standard (Clinical testing lab) Management of 3 people.
Postdoctoral Fellow in Exploratory Science and Translational Medicine Department,
May 2007 --- April 2009
- In vitro assays to characterize and determine the mode of action of therapeutic antibodies. - Set-up of cellular assays, ex vivo and in vitro models for lead candidate identification and characterization - Development of the lead candidates (Epitope mapping, antibody engineering, germlining) (e.g. anti-IL-6R mAb) - Implementation of a testing laboratory for clinical samples following GLP rules. - Establishment of a L2 lab as a strategic resource for clinical sample analysis and the development of appropriate cell-based bioassays or whole blood assays
February 2007 --- April 2007
Analysis of the neuropoietin's signaling pathway. Biochemistry, cellular biology in order to complete my PhD work.
February 2003 --- January 2007
Generation of a murine model of neurodegenerative disease (Multiple Sclerosis). Knock-Out and conditional Knock-In mice, and cytokine Inactivation (neutralizing mAbs and cytokine trap) Rôle des ligands du CNTFR dans le développement et étude de la signalisation induite pas ces cytokines dans des modèles cellulaires de cancer. Compétences acquises: Biologie cellulaire, biologie moléculaire (construction d'une souris Knock-In), Biochimie, Immunologie, neurobiologie. Teaching : « Innovations in biotechnology » Biochemistry, Master students, ISTIAA, Angers, France
February 2002 --- January 2003
Study of prion protein structure and chimeric protein. Conversion in scrapie form (Biochemistry and molecular biology) with work in a P3 lab
PhD in Pharmacology from Université de Montréal in 2007
Master's degree in Biology, protein engineering from Polytech'Clermont-Ferrand in 2002
Master's degree (DEA) in Physiologie et génétique moléculaires from Université Blaise Pascal (Clermont-II) - Clermont-Ferrand in 2002
DEUG in Sciences de la Vie from Université Blaise Pascal (Clermont-II) - Clermont-Ferrand in 1999