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Summary

the structural modification of vitamin b6 and vitamin e have been carried out during my Research work at the department of Chemistry-bmc, uppsala University that also led to serve as excellent scavengers of ros/rns. my current Research is focus here on both organoselenium and organotellurium compounds and evaluate their catalytic chain-breaking as well as hydroperoxide decomposing antioxidative properties i.e. glutathione peroxidase (gpx)-like activity. i have developed here several se/te analogues of vitamin b6 (mainly pyridoxine) and vitamin e as antioxidants and published in very good reputed journals. their catalytic chain-breaking antioxidative properties have also been evaluated in a simple lipid membrane-like, two-phase model system using HPLC. the progress of peroxidation has been followed by HPLC and analysed for conjugated diene hydroperoxide in the lipid layer. i have been working with HPLC from nearly four years. novel compounds not only quench the harmful peroxyl radicals more efficiently than α-tocopherol but also turned out to be readily regenerable by aqueous n-acetylcysteine in this model system.

i shall, therefore, the most grateful if you could kindly consider my application for this position.

i look forward to hearing from you soon at your earliest convenience.

sincerely yours,

Experiences

Current Experience

  • Researcher

    Uppsala, Sweden
    Since July 2011

    i have been working in the area of organoselenium and tellurium Chemistry and evaluated their antioxidant capacity. during my Research work at the department of Chemistry-bmc, uppsala University, i synthesized several vitamin b6 and vitamin e derivatives that also led to serve as excellent scavengers of ros/rns. my current Research is focus here on both organoselenium and organotellurium compounds and evaluate their catalytic chain-breaking as well as hydroperoxide decomposing antioxidative properties i.e. glutathione peroxidase (gpx)-like activity. these compounds not only quench the harmful peroxyl radicals more efficiently than α-tocopherol but also turned out to be readily regenerable by aqueous n-acetylcysteine in this model system. my current interest is also to introduce te-alkyl group at ortho-position to phenolic compounds and aromatic amines for their antioxidative properties. targeted novel bis-azo ebselen compounds stabilized by azo-coordination are also synthesized as Fluorescence probe to for the detection of thiols. it has been shown that toxicity is insignificant at concentrations where it could efficiently inhibit ros-production in stimulated leucocytes. it would therefore seem worth-while to test it for Treatment of diseases where the natural antioxidant systems are overwhelmed (Inflammation, stroke, Cardiovascular diseases etc.).

    I have been working in the area of organoselenium and tellurium Chemistry and evaluated their antioxidant capacity. During my research work at the Department of Chemistry-BMC, Uppsala University, I synthesized several vitamin B6 and vitamin E derivatives that also led to serve as excellent scavengers of ROS/RNS. My current research is focus here on both organoselenium and organotellurium compounds and evaluate their catalytic chain-breaking as well as hydroperoxide decomposing antioxidative properties i.e. glutathione peroxidase (GPx)-like activity. These compounds not only quench the harmful peroxyl radicals more efficiently than α-tocopherol but also turned out to be readily regenerable by aqueous N-acetylcysteine in this model system. My current interest is also to introduce Te-alkyl group at ortho-position to phenolic compounds and aromatic amines for their antioxidative properties. Targeted novel bis-azo ebselen compounds stabilized by azo-coordination are also synthesized as fluorescence probe to for the detection of thiols. It has been shown that toxicity is insignificant at concentrations where it could efficiently inhibit ROS-production in stimulated leucocytes. It would therefore seem worth-while to test it for treatment of diseases where the natural antioxidant systems are overwhelmed (inflammation, stroke, cardiovascular diseases etc.).

Area / Region

Uppsala, Sweden

Others

Driving License
  • No

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