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Summary

The structural modification of vitamin B6 and vitamin E have been carried out during my research work at the Department of Chemistry-BMC, Uppsala University that also led to serve as excellent scavengers of ROS/RNS. My current research is focus here on both organoselenium and organotellurium compounds and evaluate their catalytic chain-breaking as well as hydroperoxide decomposing antioxidative properties i.e. glutathione peroxidase (GPx)-like activity. I have developed here several Se/Te analogues of Vitamin B6 (mainly pyridoxine) and Vitamin E as antioxidants and published in very good reputed journals. Their catalytic chain-breaking antioxidative properties have also been evaluated in a simple lipid membrane-like, two-phase model system using HPLC. The progress of peroxidation has been followed by HPLC and analysed for conjugated diene hydroperoxide in the lipid layer. I have been working with HPLC from nearly four years. Novel compounds not only quench the harmful peroxyl radicals more efficiently than α-tocopherol but also turned out to be readily regenerable by aqueous N-acetylcysteine in this model system.

I shall, therefore, the most grateful if you could kindly consider my application for this position.

I look forward to hearing from you soon at your earliest convenience.

Sincerely Yours,

Experiences

Current Experience

  • Researcher Uppsala, Sweden
    Since July 2011

    I have been working in the area of organoselenium and tellurium Chemistry and evaluated their antioxidant capacity. During my research work at the Department of Chemistry-BMC, Uppsala University, I synthesized several vitamin B6 and vitamin E derivatives that also led to serve as excellent scavengers of ROS/RNS. My current research is focus here on both organoselenium and organotellurium compounds and evaluate their catalytic chain-breaking as well as hydroperoxide decomposing antioxidative properties i.e. glutathione peroxidase (GPx)-like activity. These compounds not only quench the harmful peroxyl radicals more efficiently than α-tocopherol but also turned out to be readily regenerable by aqueous N-acetylcysteine in this model system. My current interest is also to introduce Te-alkyl group at ortho-position to phenolic compounds and aromatic amines for their antioxidative properties. Targeted novel bis-azo ebselen compounds stabilized by azo-coordination are also synthesized as fluorescence probe to for the detection of thiols. It has been shown that toxicity is insignificant at concentrations where it could efficiently inhibit ROS-production in stimulated leucocytes. It would therefore seem worth-while to test it for treatment of diseases where the natural antioxidant systems are overwhelmed (inflammation, stroke, cardiovascular diseases etc.).

Area / Region

Uppsala, Sweden

Others

Driving License
  • No