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  • self-motivated, results-driven, quick-learning research manager with 22 years of experience in a CRO, and 8.5 years as the CSO of a biopharmaceutical company in Leiden, the Netherlands
  • extravert, analytical, critical, organized, collaborative, inspiring, team player
  • extensive hands-on experience in leading biopharmaceutical drug development from discovery up to and including clinical Phase 2a
  • solid experience in managing multi-disciplinary, international R&D teams of up to 15 people
  • understands researchers as well as business developers

Areas of expertise

  • biopharmaceutical drug development
    • target identification, CMC, PoC anmimal model studies, preclinical toxicology and safety pharmacology, clinical Phase 1 and 2a, quality control, regulatory affais
  • Immunology and neurodegeneration
    • neuroinflammation, proteinopathies, autoimmunity
    • cell culture, analytical techniques, animal models
  • Protein biochemistry
    • protein purification, modification, stability and analysis

Scientific Contributions

  • > 110 peer-reviewed scientific papers and book chapters
  • 6 academic co-promotorships
  • 10 patent inventorships
  • dozens of invited lectures at international scientific meetings


Current Experience

  • Chief Scientific Officer Leiden, Netherlands
    Since January 2008

    Delta Crystallon aims at the clinical development of a recombinant biopharmaceutical drug for the treatment of proteinopathies and multiple sclerosis.


    • design and management of all R&D programs
    • strategic planning and investor relationships
    • preparation of study protocols and reports, and of regulatory documents such as drug development plans, IMPD, IB, orphan drug designation applications, patent applications and scientific papers
    • Quality Control and Regulatory Affairs
    • external representation during visits to pharmaceutical companies and venture capital firms, biotech partnering meetings and scientific meetings
    • initation and maintenance of CRO relationships and contacts with external collaborators


    • successful completion of pre-clinical and clinical development of Delta Crystallon's lead compound with the demonstration of significant clinical benefit in multiple sclerosis
    • successful pre-clinical development and PoC for application of the lead compound in proteinopathies
    • successful development of a microparticulate formulation and PoC in a model for COPD

Past Experience

  • Senior scientist and Deputy Head of Division Leiden, Netherlands
    January 1992 --- December 2007

    TNO Quality of Life is a CRO in the life sciences and food health and safety industry.


    • control of strategy, personnel and finances of the Division Biomedical Research (55 fte; 12 mEuro annual turnover)
    • acquisition, design and management of international R&D program, including reporting
    • quality assurance
    • IP management
    • various representational tasks including consultancy to pharma, biotech and health food companies


    • successful completion of CRO projects for a host of national and international clients in the pharma and health food industry
    • establishment of an internationally recognized line of multiple scelrosis research
    • discovery of a candidate biopharmaceutical drug for the treatment of multiple sclerosis and proteinopathies, and successful development of a GMP manufacturing process for this protein

  • Senior Scientist Rijswijk, Netherlands
    September 1985 --- December 1991

    The TNO MBL focused on strategic and contract research, and the Immunology Department at development of peptide-based vaccines, antibody-based diagnostics, and autoimmune disorders. 


    • acquisition of projects
    • design and management of R&D projects
    • internal as well as external representations


    • successful completion of a range of R&D projects


Self Assessment :
Analytical thinkingAttention to detailCommunicativeCollaborationCreative thinkingOptimismProblem solvingResult OrientedSociabilityResponsibility


Self Assessment :
Animal models Biochemistry Cell biology Phase I R&D Scientific writingAdverse Events (AE)Allergy and immunologyAnalysisAnalytical Method ValidationAuditingBiological Drug DevelopmentBiomarkersBiopharmaceuticalsCAPACell CultureChange ControlChemistry, Manufacturing, and Controls (CMC)Clinical researchClinical study reportsClinical trial designClinical trial managementCNSCoachingCurrent Good Manufacturing Practice (CGMP)ChromatographyCleanroomCommunication SkillsCompliance with regulationsData AnalysisDrug AccountabilityDrug DevelopmentDrug DiscoveryDrug regulatory authoritiesDrug substance developmentElectrophoresisELISAEMAEnglishEntrepreneurshipEthics submission and approval processFailure Mode and Effect Analysis (FMEA)Business DevelopmentCell Based AssaysCRODue DiligenceGood Clinical Practice (GCP)Good Distribution Practice (GDP)Good Laboratory Practice (GLP)Good Manufacturing Practice (GMP)Grant Preparationgrant writing and designGraphPad PrismHistologyHPLCICH guidelinesImmunoassaysImmunologyInfectious diseasesInflammationInformed Consent ProcessInternational Project ManagementISO 9001Knowledge of the drug development processLaboratory ResearchLeadershipMammalian Cell CultureManagement ConsultingMicrosoft ExcelMicrosoft OfficeMicrosoft PowerpointMicrosoft WordMultiple dose tolerance studyOutsourcingOxidative stressPharmaceutical ResearchPharmaceutical DevelopmentPharmacodynamicsPharmacokineticsPhase IPhase IIPhotoshopPilot scale batchesPowerPointPre-clinical researchPreclinical developmentPreclinical regulations and practicesProtein chemistryProtein ExpressionProtein PurificationProteinsProteomicsPublic SpeakingQA complianceQC releaseQuality Assurance (QA)Quality ManagementRandomization and blindingRegulatory ComplianceResearchSafety trialsScientific WritingSDS-PAGESocial SkillsStability testsStandard Operating Procedure (SOP)Start-upsStrategic PlanningStudy proposalsStudy protocolsTeam LeadershipTranslational MedicineUnderstanding of regulatory guidelinesUnderstand how results translate to practiceVenture CapitalWestern BlottingWriting Study Procedures and SOPs

Skills and Expertise

Self Assessment :
Analytical skills Analyze data Build and manage the Trial Master File (TMF) Create SOPs Control data Build the CMC development plan Develop clinical trial protocols Develop protocols Guide students Interact with physicians Interpret data Lab scale batches Report data Search literature on clinical trials Technology research Write papers Write protocolsAct as the main line of communication between the sponsor and the investigatorAdjust processes and methodsAdvise on strategyAlzheimerAnalyze proteinApprove monitoring reportsAttend investigator meetingAttend at steering committee meetingsAttend seminarsAttend seminars, courses and meetings within and outside the companyCalculate trial timelinesCell cultureChemistry Manufacturing and Controls (CMC) activitiesCoach staffcollaborate in research projects at universitiesCommunicate effectively on different company levelsConduct literature searchesCoordinate projectsCreate standard operating procedure (SOP)Create study documentsCreates a collaborative team environmentDesign clinical trialDesign protocolDesign scientific experimentsDevelop clinical hypothesesDevelop business planEvaluate physico-chemical data of lab scale/pilot scale batchesEvaluate protocolsEvaluate stability data and impurity identification/synthesisEvaluate stability data Execute scientific projectsInteract with CROsInteract with ethics committeeInteract with KOLInteract with pharmacistsInteract with pre-clinical scientistsInteract with regulatory stakeholdersInteract with statisticiansInteract with physiciansInteract with nursesInterpret analytical resultsInterpret dataInterpret research resultsInterpret scientific dataManage multiple projectsManage study budgetManage study supplyManage trial master file (TMF)Manufacture of non-GMP and GMP batchesManuscript preparation and reviewNegotiationObtain grantsOral presentationOrganise meetingsOrganise steering committeePresent data at congressproject managementPublication of articlesR&DResearch at universitiesSelect contractors Set up research projectsSet up a clinical studySupervise analysts and researchersUnderstand protocolsWrite documents


  • PhD in Biochemistry from University Leiden in 1985
  • MSc Biochemistry in Biochemistry from University Leiden in 1981
  • BSc in Biology from University Leiden in 1978

Training and Certification

  • GLP study director in 1998 Certification


BrightOwl Assessment:
Self Assessment:
Full Proficiency
Professional Proficiency
Elementary Proficiency

Work Preferences

  • Notice Period:
    1 week
  • Positions I am interested in:
    Associate Scientist Associate Director - Head of Preclinical Immunology - Bacterial Vaccines Biomedical Scientist Chief Strategy Officer CSO Development Manager Freelance Science Writer GMP Coordinator Lead Consultant Management Consultant Manager Managing Director Principal Scientist R&D Director R&D manager R&D Scientist Scientific Advisor Scientific consultant Scientific Officer Scientific Writer Senior Consultant Senior Project Manager (PM) Senior Scientist senior research associate Team Leader
  • Locations I am interested in:
  • Work From Home:
    Yes, 0 to 5 days per week
  • Work Regime:
    Permanent position :    100% FTE
    BrightOwl freelancer :    40 Hours per week :    100% Free Per Month(in coming months)
    BrightOwl employee :    100% FTE
  • International:


    Expert has 1 publications (Will be avalible with full profile)

Area / Region

Leiden, Netherlands


Driving License
  • Yes