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Summary

my studies in theoretical Physics and medicine together with a hands-on Career in Pharmaceutical Drug Discovery & development have enabled me to develop a totally novel innovative approach to quantitative systems pharmacology computer-based Drug Development. during my work at the janssen research foundation under the mentorship of the best drug hunter in history, dr. paul janssen, i have learned to overcome conceptual barriers between basic and Clinical research and get an excellent mastery of Translational Medicine in CNS diseases. i was involved in the pharmacology and the Clinical Development of galantamine for alzheimer’s disease, while at the same time leading a research team in targets of tangle Pathology. since 2001 i have devoted my Career to developing mechanism-based computer models of biophysically realistic networks with a special emphasis on making these results actionable for CNS drug R&D in an entrepreneurial spirit in a small bio-Informatics company. i strongly believe that re-Engineering Drug Discovery and development by refocusing on circuits and their emergent properties rather than single targets can make a positive contribution to the successful development of new CNS drugs which address the unmet medical needs of many patients. within the alzheimer association i have created a professional interest association on ‘big data to smart data’, as my approach to Data Science is different from traditional bio-Informatics in that it incorporates domain expertise to develop mechanism-based computer models with high predicatibility. professional experience - Drug Discovery and development research at janssen research foundation in Alzheimer's disease - Assistant Professor at University of pennsylvania - development of computer-based mechanistic models of the brain, useful in drug R&D for CNS disorders specialities: Translational Medicine in CNS disorders Drug Discovery application of mathematical models to brain disorders and Neuropharmacology

Experiences

Current Experience

  • Adjunct Faculty


    Since January 2010

  • Adjunct Associate Professor


    Since January 2003
    adjunct Associate Professor, school of Medicine, University of pennsylvania Adjunct Associate Professor, School of Medicine, University of Pennsylvania

  • Scientific Liaison Officer


    Since January 2002
    responsable for the long-term Strategy of the computational Neuropharmacology modeling in Psychiatry and cognition and contact with clients. leads virtual Drug Discovery project around a 'lean' profile compound for schizophrenia. Responsable for the long-term strategy of the computational neuropharmacology modeling in psychiatry and cognition and contact with clients. Leads virtual Drug discovery project around a 'lean' profile compound for schizophrenia.

  • Chief Scientific Officer


    Since November -0001

Past Experience

  • Research fellow

    January 1999 --- January 2002
    in charge of the alzheimer Drug Discovery group; worked on tau and abeta programs

  • Visiting professor

    September 1992 --- December 2001

  • Research fellow

    November 1984 --- December 2001
    in charge of Alzheimer's disease Drug Discovery. helped develop galantamine (reminyl-razadyne)

Knowledge

LinkedIn Assessment :
Drug DiscoveryTranslational MedicinepharmacologyNeuroscienceBiophysicsProteomicsIn VitroDrug DevelopmentNeurologyBiomarkersClinical trialsPsychiatryBiotechnologyNeuropharmacologyTranslational ResearchClinical researchIn VivoImmunologyCell biologyAnimal ModelsQuantitative ResearchMathematical ModelingCellLifesciencesPharmacodynamicsPharmacokineticsMicroscopyClinical DevelopmentLife Sciences

Education

  • MBA in Pharmaceutical Executive from Drexel University - LeBow College of Business in 2009
  • Master's degree in Pharmaceutical Sciences from Free University of Brussels in 1986
  • Bachelor in Medicine from Universiteit Antwerpen in 1984
  • PhD in Biophysics from University of Antwerp in 1984
  • Bachelor in Physics in Quantum mechanics, biophysics from University of Antwerp in 1975
  • in from StMichielscollege in 0000

Area / Region

United States

Others

Driving License
  • No

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