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Summary

My studies in theoretical physics and medicine together with a hands-on career in pharmaceutical drug Discovery & Development have enabled me to develop a totally novel innovative approach to Quantitative Systems Pharmacology computer-based drug development. During my work at the Janssen Research Foundation under the mentorship of the best drug hunter in history, Dr. Paul Janssen, I have learned to overcome conceptual barriers between basic and clinical research and get an excellent mastery of Translational Medicine in CNS diseases. I was involved in the pharmacology and the clinical development of galantamine for Alzheimer’s disease, while at the same time leading a research team in targets of tangle pathology. Since 2001 I have devoted my career to developing mechanism-based computer models of biophysically realistic networks with a special emphasis on making these results actionable for CNS drug R&D in an entrepreneurial spirit in a small bio-informatics company. I strongly believe that re-engineering drug discovery and development by refocusing on circuits and their emergent properties rather than single targets can make a positive contribution to the successful development of new CNS drugs which address the unmet medical needs of many patients. Within the Alzheimer Association I have created a Professional Interest Association on ‘Big Data to Smart Data’, as my approach to Data Science is different from traditional bio-informatics in that it incorporates domain expertise to develop mechanism-based computer models with high predicatibility. Professional Experience - Drug Discovery and Development Research at Janssen Research Foundation in Alzheimer's disease - Assistant Professor at University of Pennsylvania - Development of computer-based mechanistic models of the brain, useful in Drug R&D for CNS disorders Specialities: Translational Medicine in CNS Disorders Drug Discovery Application of mathematical models to brain disorders and neuropharmacology

Experiences

Current Experience

  • Adjunct Faculty
    Since January 2010

  • Adjunct Associate Professor
    Since January 2003
    Adjunct Associate Professor, School of Medicine, University of Pennsylvania

  • Scientific Liaison Officer
    Since January 2002
    Responsable for the long-term strategy of the computational neuropharmacology modeling in psychiatry and cognition and contact with clients. Leads virtual Drug discovery project around a 'lean' profile compound for schizophrenia.

  • Chief Scientific Officer
    Since November -0001

Past Experience

  • Research fellow
    January 1999 --- January 2002
    In charge of the Alzheimer drug discovery Group; worked on tau and Abeta programs

  • Visiting professor
    September 1992 --- December 2001

  • Research fellow
    November 1984 --- December 2001
    In charge of Alzheimer's disease drug discovery. Helped develop galantamine (Reminyl-Razadyne)

Knowledge

LinkedIn Assessment :
Drug DiscoveryR&DTranslational MedicinepharmacologyNeuroscienceBiophysicsProteomicsIn VitroDrug DevelopmentNeurologyBiomarkersClinical trialsPsychiatryBiotechnologyNeuropharmacologyTranslational ResearchClinical researchIn VivoImmunologyCell biologyAnimal ModelsQuantitative ResearchMathematical ModelingCellLifesciencesPharmacodynamicsPharmacokineticsMicroscopyClinical DevelopmentLife Sciences

Education

  • MBA in Pharmaceutical Executive from Drexel University - LeBow College of Business in 2009
  • Master's degree in Pharmaceutical Sciences from Free University of Brussels in 1986
  • Bachelor in Medicine from Universiteit Antwerpen in 1984
  • PhD in Biophysics from University of Antwerp in 1984
  • Bachelor in Physics in Quantum mechanics, biophysics from University of Antwerp in 1975
  • in from StMichielscollege in 0

Area / Region

United States

Others

Driving License
  • No