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Summary

i’m a bioprocess Engineer with an extensive expertise in upstream and downstream processes for animal cells based technologies. i also worked in bioreactors design and Manufacturing were i contributed to the final development of prototypes of single-use bioreactors. later, on another project, as Quality Control Laboratory manager i successfully implemented process changes which led my team to significantly enhance the yield of Analysis. the techniques i mastered include Mammalian and bacterial Cell cultures in bioreactors, filtration (tff), protein Analysis (SDS-PAGE, Western blot, ief, and ELISA), Protein Purification (Liquid chromatography, iex) and protein quality/activity evaluation (ms, surface plasmon resonance, lectin-blot). i'm currently open to new opportunities in the biopharmaceutical sector

Experiences

Current Experience

  • PhD candidate in Chemical Engineering - Bioprocess Engineering


    Since May 2013
    optimizing the quality (glycosylation) of therapeutic Proteins produced in Mammalian Cell Culture Optimizing the quality (glycosylation) of therapeutic proteins produced in mammalian cell culture

Past Experience

  • Teaching Assistant in Biochemical Engineering

    September 2014 --- December 2015
    1] bioprocess Engineering • gas / liquid mass transfer Characterization • modeling cell growth, substrate utilization kinetics and recombinant Protein production • Mammalian and bacterial Cell Culture in Lab scale bioreactors 2] Downstream processing • tangential flow filtration (tff) • ElectrophoresisLiquid chromatography • surface plasmon resonance using biacore™ spr systems

  • Pharmaceutical Quality Control Laboratory Manager

    November 2012 --- April 2013
    departments of Microbiology and physico-Chemistry. • managing a team of 6 analysts in a GMP working environment • leading daily meetings in order to: plan the analyzes, discuss the results and solve technical issues • key contact with the clients and subcontractors • ensuring the continuous improvement of the global Quality System

  • Engineering Consultant

    October 2011 --- April 2013

  • Product Development Engineer - Project leader

    December 2011 --- July 2012
    development of a method for the assembly of a single-use bioreactor for vaccine production • assembly of Polymer materials (using: UV adhesives, plastic welding techniques: laser, induction, mirror, ultrasonic) • surface hydrophilization • designing a model of accelerated aging of Polymer materials • mechanical Testing ( tensile tests, t-peel tests) • biocompatibility assessment • investigating on plastic cutting techniques implementable in Cleanroom • weekly advancement meetings with the Engineering team and writing of the final • report of the project

  • Internship, scientist

    July 2009 --- October 2009
    • heterologous Protein Expression in BacteriaCell cultures and cloning, Electrophoresis, Fluorescence Microscopy.

Knowledge

LinkedIn Assessment :
BiopharmaceuticalsUpstream & downstream bioprocessingProtein Quality characterizationSingle use bioreactors designFDA GMPFluid DynamicsANSYSCloningProtein ElectrophoresisELISAICH guidelines

Skills and Expertise

Self Assessment :
Upstream ProcessesDownstream ProcessesMammalian Cell CulturesBioreactors operationLiquid chromatographySurface Plasmon resonnanceSingle use bioreactors

Education

  • Ph.D. in BioProcess Engineering in Chemical Engineering from École Polytechnique de Montréal in 2017
  • Master of bioengineering, Chemistry and Bioindustry in Biotechnologies from Université libre de Bruxelles in 2011
  • Bachelor of bioengineering in Engineering from Université libre de Bruxelles in 2009
  • High School Degree in Sciences and Mathematics from Athénée Charles Janssens in 2005

Training and Certification

  • Quality Risk Management (ICH Q9, FMEA) in 2012 Training
  • Validation: V-cycle (PVP, URS, IQ-OQ-PQ), Cleaning Validation in 2012 Training
  • Computerized System Validation in 2013 Certification

Languages

BrightOwl Assessment:
Self Assessment:
French
Native
English
Full Proficiency
Dutch
Professional Proficiency

Publications

    Expert has 2 publications (Will be avalible with full profile)

Area / Region

Montreal, QC, Canada

Others

Driving License
  • Yes

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