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I obtained my MD and a PhD in medical sciences at the University of Antwerp and worked as a postdoctoral fellow in the laboratory of Physiology.  I worked for two years in the clinical pharmacology (Phase 1) unit of Janssen as Medical Director. Afterwards I was assistant professor Pharmacology at th eUniversity of Antwerp for 3 years> Currently I hold the position of Medical Director Early Phase at SGS.

Specialties: cardiovascular research, heart failure cardiac physiology & disease, contractility endothelial function neuregulin/ErbB system in the heart rodent cardiovascular disease models cell culture molecular and cellular biology, clinical pharmacology, eraly phase clinical trials, GCP, earlu phase study design, firts-in-human studies


Past Experience

  • Associate Professor-Tenure Track Docent
    October 2013 --- September 2016

    Pathophysiology and Pharmacology

  • Medical Director Merksem, Antwerpen, België
    October 2012 --- September 2013
    phase 1 clinical studies, early clinical development, clinical pharmacology, safety assessment, protocol revision, ...

  • Clinical Research Physician
    October 2011 --- September 2012
    Principal investigator of phase 1 clinical studies including safety assessment, protocol revision, ... Member of the Cardiovascular Safety Group

  • Postdoctoral fellow
    August 2008 --- September 2011
    Study on the role of NRG/ErbB signaling in cardiovascular diseases Teaching Pathophysiology in 3rd Bachelor Farmaceutical Sciences

  • Trainee Cardiology
    January 2007 --- January 2008

  • Clinical Research fellow
    January 2006 --- January 2007

  • PhD Fellowship, FWO
    January 2001 --- January 2006
    In this PhD project I studied the role of neuregulin-1 in the communication between cardiac endothelium and cardiomyocytes in adult cardiac tissue

  • trainee Internal Medicine
    September 2000 --- September 2001


Self Assessment :
FlexibilityWillingness to compromiseTrustSociabilitySelf-disciplineProblem solvingKindnessOptimismInterest in knowledgeIndependenceCuriosityApproachabilityAttention to detailAnalytical thinkingCollaboration


Self Assessment :
Animal models Phase I Scientific writingA rising single dose tolerance studyActions and modes of action of human physiology R&DAntibodiesBioavailabilityBiomarkersCAPACardiologyCardiovascular diseasesCell CultureClinical pharmacologyClinical researchClinical Study DesignClinical study reportsClinical trial audits and inspectionsClinical trial managementClinical trialsDrug InteractionEarly development stageEmergency medicineEthics submission and approval processGCPGood Clinical Practice (GCP)HospitalsICH-GCPImmunofluorescenceImmunohistochemistry (IHC)ImmunoprecipitationIn VitroIn VivoInformed Consent ProcessInternal medicineInterpret clinical trial resultsKnowledge of the drug development processMicroscopyMicrosoft ExcelMicrosoft OfficeMolecular & Cellular BiologyMultiple dose tolerance studyOxidative stressPatient Screening and RecruitmentPCRpeople managementPharmaceutical IndustryPharmacokineticsPhase IPhase IIPowerPointPre-clinical researchPrinciples and ethics of clinical researchProtein ExpressionProtocolQuantitative PCR (qPCR)Safety trialsScientific WritingScientific methodologySearch literature on clinical trialsSerious Adverse Event (SAE)SOPStatisticsTeam LeadershipUnderstand how results translate to practiceUnderstand levels of research evidenceWestern BlottingWriting Study Procedures and SOPsInformed Consent Documents
LinkedIn Assessment :
Internal medicineHeart Failuremolecular biologyCell CulturescienceClinical trialsClinical researchTeachingResearchMicroscopyIn VivoELISAPCRImmunohistochemistryqPCRCardiologypharmacologyMedicineLife SciencesPhysiologyClinical DevelopmentLaboratoryPharmaceutical Industry

Skills and Expertise

Self Assessment :
Analyze data Assure medical quality Create SOPs Guide students Interact with physicians Interact with nurses Interpret data Receptor Pharmacology Report data Search literature on clinical trials Write papersAdjust methodsAdjust processes and methodsAdverse event reportingAdvise on medical perspectivesApprove consent documentsApprove queriesAssess adverse reactionsAssess subject safetyAssure medical qualityAttend investigator meetingAttend seminarsBiomarker ResearchCapture data on source documentsCoach staffCommunicate with sponsorComplete case report form (CRF)Complete study proceduresConduct close-out visitsConduct literature searchesConduct research at universitiesConduct the trialConfirm protocol compliancecoordinating research projectsCreate SOPsCreates a collaborative team environmentData analysisData entryDesign scientific projects (in biology)Develop clinical hypothesesDevelop ICH/GCP compliant processesDocument adverse eventsDocument employees training requirementsEnsure data integrityEnsure good clinical practice (GCP)Ethics committee submissionsEvaluate protocolsExecute scientific projectsFeasibility analysis of proposed trial designImplement Quality Management System (QMS)Interact with ethics committeeInterpret datalifescienceManage contractors Manage subject safetymanaging a small teamManuscript preparationManuscript preparation and reviewNegotiate protocol details Observe trends in dataObtain grantsOral presentationParticipate in medical reviewPatient recruitmentPrepare external auditsPresent data at congressProtocol managementProvide benefit risk assessmentProvide input to process improvement initiativesProvide medical insightsPublish scientific projectsQuality control processQuality testing of Investigational Medicinal Products (IMPs)Read medical literatureReferral lettersRegulatory documentationRegulatory submissionsReport dataReport deaths to regulatory authoritiesPublication of articlesReport non-compliance incidentsReport serious adverse events (SAE)Resolves queriesRespond to audit findingsReview exclusion criteriaReview inclusion criteriaReview study protocolsScreen patientsSelect contractors Solve problemsStatistical analysisTrain on site staffUse laser doppling imaging techniqueUse western blotting techniqueWrite papers teaching


  • MD, PhD in Medical Siences from Universiteit Antwerpen in 2000
  • in Latin-Mathematics from Onze-Lieve-Vrouw-instituut (Pulhof) in 1993

Training and Certification

  • Lean Management in 2016 Training
  • Simcyp’s intensive workshops (Centara), Model-based drug development: Incorporating population variability into mechanistic prediction of PK and modelling PK-PD in 2014 Training
  • Certificate in Human Pharmacology-Faculty of Pharmaceutical Medicine: Module 1 Exploratory drug development-King’s College London in 2012 Training
  • First 21 days as supervisor in 2012 Training
  • First Line Leader I: leading people in 2012 Training
  • Elective course in ‘ICH-GCP, Antwerp University Hospital and the University of Antwerp, Danny Mathysen. Evaluation: multiple choice test with minimal score 70%. Certificate is valid for 2 years in 2016 Certification
  • Advanced Life Support in 2012 Certification
  • Good Clinical Practice refresher course. Dr Herman Pieterse Profess Medical Consultancy in 2012 Certification
  • Practical implementation of ICH-GCP/ European Directive 2001/20/EC in clinical trials in 2011 Certification
  • Certificate Electrocardiography in 1998 Certification
  • Advanced Life Support Certification


BrightOwl Assessment:
Self Assessment:
Professional Proficiency
Elementary Proficiency

Work Preferences

  • Work From Home:
    Yes, 2 to 4 days per week
  • Work Regime:
    Permanent position :    FTE 60-80% FTE
    BrightOwl freelancer :    24-36h/week Hours per week
  • International:

Area / Region

Antwerpen, België


Driving License
  • Yes